These tails are topic to a number of submit-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, Solicitor law firms sumoylation and methylation (reviewed in 1 ). The exception to the rule is the DOT1 household, members of which methylate K79 within the globular area of histone H3 and that are structurally not related to SET-area proteins 4 - 6 Current work means that SET-area-containing proteins methylate a number of proteins in addition to histones (see later)