Compared with mouse thymocytes, mouse ES cells comprise greater levels of complete genomic H3K4me3 and have greater H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In settlement with this, world decreases in H3K4me3 levels occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 As well as, there are dynamic adjustments in H3K4me3 profiles at specific units of genes throughout ES cell differentiation.

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