Reducing your consumption of excessive-calorie meals will scale back your calorie intake and provide help to to lose weight. The exception to the rule is the DOT1 family, members of which methylate K79 in the globular area of histone H3 and which are structurally not associated to SET-domain proteins four - 6 Current work suggests that SET-area-containing proteins methylate a couple of proteins along with histones (see later)