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The initial doses are to be administered in a healthcare setting because the intracavernous injections can increase peripheral blood levels, resulting in low blood pressure. Alprostadil intracavernosal injection is a second-line option to PDE5 inhibitors in ED medications for those who cannot tolerate or receive them due to drug interactions or side effects. Alprostadil is a prostaglandin that causes vasodilation, or widening of blood vessels, with localized injection allowing blood flow and entrapment in the penis. To use this product, the intended injection site must first be swabbed with an alcohol wipe before injecting into the penis, avoiding any visible veins. With continued use, alternate sides of the penis should be injected.

In May 2002, Lilly ICOS reported to the American Urological Association that clinical trial testing demonstrated that tadalafil was effective for up to 36 hours, and one year later, the FDA approved tadalafil. TADALAFIL contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis